Autoantibodies against C1q: view on association between systemic lupus erythematosus disease manifestation and C1q autoantibodies.
نویسندگان
چکیده
_______________________________ Correspondence to: Daniela Monova, 24 Veliko Turnovo str, Sofia 1504, Bulgaria, tel++3598437705 e-mail: [email protected] Autoantibodies Against C1q: View on Association Between Systemic Lupus Erythematosus Disease Manifestation and C1q autoantibodies D. Monova, S. Monov, K. Rosenova, T. Argirova Medical University Sofia, Department of Internal Medicine, Sofia University, Department of Biochemistry, Sofia
منابع مشابه
Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis
BACKGROUND Lupus nephritis is considered to be a principal cause of morbidity and mortality in SLE. Few studies focus on the association between anti-C1q antibodies in circulation and renal C1q deposition in human lupus nephritis. In this study, we detected the serum levels of C1q, presence of anti-C1q antibodies in circulation, renal C1q deposition and further analyzed their associations with ...
متن کاملFc γ RIIA Genotypes and Its Association with Anti-C1q Autoantibodies in Lupus Nephritis (LN) Patients from Western India
To identify Fc γ RIIA genotypes in Systemic Lupus Erythematosus (SLE) patients and their association with anti-C1q antibodies. Methods. Fc γ RIIA genotyping was done in eighty Indian SLE patients and eighty healthy controls using allele-specific PCR. Anti-C1q antibodies were measured by ELISA. Results. LN patients showed higher SLEDAI (6-32) as compared to SLE patients without renal manifestati...
متن کاملAnti-C1q autoantibodies do not correlate with the occurrence or severity of experimental lupus nephritis.
BACKGROUND In systemic lupus erythematosus patients, a strong association between the occurrence of antibodies against complement C1q (anti-C1q) and lupus nephritis can be observed. However, the predictive value of anti-C1q titres for a renal flare remains to be determined. Increasing titres of anti-C1q before the occurrence of clinical apparent nephritis might not only serve as a clinical para...
متن کاملAnti-C1q Antibodies as a Follow-Up Marker in SLE Patients
In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measure...
متن کاملAnti-C1q Autoantibodies, Novel Tests, and Clinical Consequences
Although anti-C1q autoantibodies have been described more than four decades ago a constant stream of papers describing clinical associations or functional consequences highlights that anti-C1q antibodies are still hot and happening. By far the largest set of studies focus on anti-C1q antibodies is systemic lupus erythematosus (SLE). In SLE anti-C1q antibodies associate with involvement of lupus...
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ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 61 6 شماره
صفحات -
تاریخ انتشار 2002